Linker-Length Landscape Mapping Enables Coupling of Diverse Synthetic Chemically Induced Dimerization Systems to Molecular Readouts
Published in bioRxiv (Preprint), 2026
We map how linker length couples diverse synthetic chemically induced dimerization (CID) systems to fluorescent sensor readouts, yielding sensors with dynamic ranges up to 1270% in mammalian cells.
Pan Y, Kang S, **Nakajima An D**, Yu Y, DiMaio F, Gu L. Linker-Length Landscape Mapping Enables Coupling of Diverse Synthetic Chemically Induced Dimerization Systems to Molecular Readouts. bioRxiv; 2026. doi: https://doi.org/10.64898/2026.07.01.735888 https://www.biorxiv.org/content/10.64898/2026.07.01.735888v1
